An EPA metabolite
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(±)11(12)-DiHETE

Item No. 10466

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11,12-dihydroxy-5Z,8Z,14Z,17Z-eicosatetraenoic acid
CAS Number
867350-92-3
Molecular Formula
C20H32O4
Formula Weight
336.5
Purity
≥98%
Formulation (Request formulation change)
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 0.5 mg/ml
SMILES
CC/C=C\C/C=C\C[C@@H](O)[C@H](O)C/C=C\C/C=C\CCCC(O)=O
InChi Code
InChI=1S/C20H32O4/c1-2-3-4-5-9-12-15-18(21)19(22)16-13-10-7-6-8-11-14-17-20(23)24/h3-4,6,8-10,12-13,18-19,21-22H,2,5,7,11,14-17H2,1H3,(H,23,24)/b4-3-,8-6-,12-9-,13-10-/t18-,19-/m1/s1
InChi Key
DNPZYIPMAWRQQE-LZVBJOTISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 µg

    $116

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    50 µg

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    100 µg

    $406

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    Product Description

    (±)11(12)-DiHETE is a dihydroxy metabolite of EPA produced by cytochrome P450-mediated epoxide formation and subsequent hydrolysis by epoxide hydrolase. Plasma levels of (±)11(12)-DiHETE are increased over baseline after an oral dose of 1008 mg EPA.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schuchardt, J.P., Schneider, I., Willenberg, I., et al. Increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acid levels in human plasma after a single dose of long-chain omega-3 PUFA. Prostaglandins Other Lipid Mediat. 109-111, 23-31 (2014).

    Product Citations

    Sun, P., Lin, D.H., Yue, P., et al. High potassium intake enhances the inhibitory effect of 11,12-EET on ENaC. J. Am. Soc. Nephrol. 21(10), 1667-1677 (2010).