A DHA epoxygenase metabolite
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(±)10(11)-EpDPA

Item No. 10471

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4Z,7Z)-rel-9-[(2R,3S)-3-(2Z,5Z,8Z)-2,5,8-undecatrien-1-yl-2-oxiranyl]-4,7-nonadienoic acid
CAS Number
895127-65-8
Synonyms
  • (±)10,11-EDP
  • (±)10,11-EpDPE
  • (±)10,11-epoxy DPA
  • (±)10,11-epoxy Docosapentaenoic Acid
Molecular Formula
C22H32O3
Formula Weight
344.5
Purity
≥95%
Formulation (Request formulation change)
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mLDMSO: 20 mg/mLEthanol: 50 mg/mLEthanol:PBS(pH 7.2) (1:1): 0.5 mg/mL
SMILES
CC/C=C\C/C=C\C/C=C\C[C@@H](O1)[C@@H]1C/C=C\C/C=C\CCC(O)=O.CC/C=C\C/C=C\C/C=C\C[C@H](O2)[C@H]2C/C=C\C/C=C\CCC(O)=O
InChi Code
InChI=1S/2C22H32O3/c2*1-2-3-4-5-6-7-8-11-14-17-20-21(25-20)18-15-12-9-10-13-16-19-22(23)24/h2*3-4,6-7,10-15,20-21H,2,5,8-9,16-19H2,1H3,(H,23,24)/b2*4-3-,7-6-,13-10-,14-11-,15-12-/t2*20-,21+/m10/s1
InChi Key
IUSGTMAKNFGMSK-YMDXMTBESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    (±)10(11)-EpDPA is a docosahexaenoic acid (DHA; Item No. 90310) epoxygenase metabolite, derived via epoxidation of the 10,11-double bond of DHA. It has been detected in rat brain and spinal cord, as well as human serum, and acts as a substrate for soluble epoxide hydrolase with a Km value of 5.1 µM.1,2 (±)10(11)-EpDPA and other epoxy metabolites of DHA are reported to demonstrate antihyperalgesic activity in inflammatory and neuropathic pain models and to potently inhibit angiogenesis and tumor growth in in vitro assays.1,3

    WARNING This product is not for human or veterinary use.