An inhibitor of gut-derived serotonin biosynthesis
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LP-533401

Item No. 10492

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-amino-6-[2,2,2-trifluoro-1-(3'-fluoro[1,1'-biphenyl]-4-yl)ethoxy]-4-pyrimidinyl]-L-phenylalanine
CAS Number
945976-43-2
Molecular Formula
C27H22F4N4O3
Formula Weight
526.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS(pH7.2) (1:2): 0.33 mg/mlDMSO: 5 mg/ml
λmax
246 nm
SMILES
NC1=NC(C2=CC=C(C[C@H](N)C(O)=O)C=C2)=CC(OC(C(F)(F)F)C3=CC=C(C4=CC(F)=CC=C4)C=C3)=N1
InChi Code
InChI=1S/C27H22F4N4O3/c28-20-3-1-2-19(13-20)16-8-10-18(11-9-16)24(27(29,30)31)38-23-14-22(34-26(33)35-23)17-6-4-15(5-7-17)12-21(32)25(36)37/h1-11,13-14,21,24H,12,32H2,(H,36,37)(H2,33,34,35)
InChi Key
JZWUKILTKYJLCN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $43

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    5 mg

    $108

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    10 mg

    $151

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    25 mg

    $269

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    Product Description

    LP-533401 is an inhibitor of tryptophan 5-hydroxylase 1 (Tph1) that blocks the biosynthesis of gut-derived serotonin, completely inhibiting serotonin production in Tph1-expressing cells at a dose of 1 µM.1 It prevents the development of and fully rescues, in a dose-dependent manner, osteoporosis in ovariectomized and aged mice.1,2 LP-533401 has also been used to elucidate the role of gut-derived serotonin in pulmonary hypertension and leukemia in mice.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yadav, V.K., Baliahi, S., Suresh, P.S., et al. Inhibition of gut-derived serotonin synthesis: A potential bone anabolic treatment. Nat. Med. 16(3), 308-312 (2010).

    2. Inose, H., Zhou, B., Yadav, V.K., et al. Efficacy of serotonin inhibition in mouse models of bone loss. J. Bone Miner. Res. 26(9), 2002-2011 (2011).

    3. Abid, S., Houssaini, A., Chevarin, C., et al. Inhibition of gut- and lung-derived serotonin attenuates pulmonary hypertension in mice. Am. J. Physiol. Lung Cell Mol. Physiol. 303(6), L500-508 (2012).

    4. Krevvata, M., Silva, B.C., Manavalan, J.S., et al. Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts. Blood 124(18), 2834-2846 (2014).