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JWH 018 N-(5-chloropentyl) analog

Item No. 10521

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1-(5-chloropentyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone
CAS Number
1445578-56-2
Molecular Formula
C24H22ClNO
Formula Weight
375.9
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:2): 0.3 mg/mlDMSO: 10 mg/ml
λmax
218, 246, 314 nm
SMILES
O=C(C1=CN(CCCCCCl)C2=C1C=CC=C2)C3=C4C(C=CC=C4)=CC=C3
InChi Code
InChI=1S/C24H22ClNO/c25-15-6-1-7-16-26-17-22(20-12-4-5-14-23(20)26)24(27)21-13-8-10-18-9-2-3-11-19(18)21/h2-5,8-14,17H,1,6-7,15-16H2
InChi Key
NZQRTHJPVKPTBV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    JWH 018 is a synthetic cannabinoid (CB) that potently activates the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors (Ki = 9.0 and 2.94 nM, respectively).1 This cannabimimetic compound has frequently been found in herbal blends.2,3,4 JWH 018 N-(5-chloropentyl) analog differs structurally from JWH 018 by having chlorine added to the 5 position of the pentyl chain. The biological activities of this compound have not been characterized. This product is intended for forensic and research applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug Alcohol Depend. 60(2), 133-140 (2000).

    2. Auwärter, V., Dresen, S., Weinmann, W., et al. “Spice” and other herbal blends: Harmless incense or cannabinoid designer drugs? J. Mass Spectrom. 44(5), 832-837 (2009).

    3. Lindigkeit, R., Boehme, A., Eiserloh, I., et al. Spice: A never ending story? Forensic Sci. Int. 191(1-3), 58-63 (2009).

    4. Uchiyama, N., Kikura-Hanajiri, R., Kawahara, N., et al. Identification of a cannabimimetic indole as a designer drug in a herbal product. Forensic Toxicol. 27(2), 61-66 (2009).