A MKLP-2 inhibitor
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Paprotrain

Item No. 10524

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
αZ-(3-pyridinylmethylene)-1H-indole-3-acetonitrile
CAS Number
57046-73-8
Synonyms
  • Passenger Proteins Transport Inhibitor
Molecular Formula
C16H11N3
Formula Weight
245.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.1 mg/mlEthanol: 0.2 mg/ml
λmax
216, 278, 365 nm
SMILES
[H]/C(C1=CN=CC=C1)=C(C2=CN([H])C3=C2C=CC=C3)/C#N
InChi Code
InChI=1S/C16H11N3/c17-9-13(8-12-4-3-7-18-10-12)15-11-19-16-6-2-1-5-14(15)16/h1-8,10-11,19H/b13-8+
InChi Key
YMYYQRZCCKBFBE-MDWZMJQESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $62

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    10 mg

    $86

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    Product Description

    Paprotrain, PAssenger PROteins TRAnsport INhibitor, is the first known inhibitor of MKLP-2. It is a cell-permeable, reversible inhibitor uncompetitive with ATP (Ki = 3.4 μM) and noncompetitive with microtubules (Ki = 1.6 μM), demonstrating ATPase inhibition of basal and microtubule-stimulated activities with IC50 values of 1.35 and 0.83 μM, respectively.1 Paprotrain does not inhibit twelve additional kinesins, including the closely related kinesin-6 motors MKLP-1 and MPP1.1 Incubation with 10-50 μM paprotrain results in binucleated cells, perturbing relocation of Aurora B kinase and survivin without affecting microtubule polymerization.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tcherniuk, S., Skoufias, D.A., Labriere, C., et al. Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Angew. Chem. Int. Ed. Engl. 49, 8228-8231 (2010).