Substrate for JmjC domain-containing class of histone demethylases
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Histone H3 Trimethyl Lys9 Peptide

Item No. 10530

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • H3K9me3 Peptide
Formula Weight
1601.0
Formulation (Request formulation change)
A lyophilized peptide
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $206

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    Product Description

    Histone H3 undergoes many modifications including acetylation, methylation, and phosphorylation that are important for regulation of gene transcription.1 This histone H3 peptide contains a trimethylated lysine residue at position nine which is a substrate for several of the JmjC domain-containing class of histone demethylases. JMJD2A and JMJD2D exhibit higher affinity with H3K9me3 compared to H3K9me2.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bhaumik, S.R., Smith, E., and Shilatifard, A. Covalent modifications of histones during development and disease pathogenesis. Nat. Struct. Mol. Biol. 14(11), 1008-1016 (2007).

    2. Couture, J.-F., Collazo, E., Ortiz-Tello, P.A., et al. Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat. Struct. Mol. Biol. 14(8), 689-695 (2007).