Inhibitor of NOS enzymes
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

NG-amino-L-Arginine (hydrochloride)

Item No. 10554

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N5-(hydrazinyliminomethyl)-L-ornithine, monohydrochloride
CAS Number
1031799-40-2
Molecular Formula
C6H15N5O2 • HCl
Formula Weight
225.7
Purity
≥97%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
NNC(NCCC[C@H](N)C(O)=O)=N.Cl
InChi Code
InChI=1S/C6H15N5O2.ClH/c7-4(5(12)13)2-1-3-10-6(8)11-9;/h4H,1-3,7,9H2,(H,12,13)(H3,8,10,11);1H
InChi Key
YGVMJVSXFJRHGQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $59

    Add

    10 mg

    $106

    Add

    25 mg

    $250

    Add

    50 mg

    $439

    Add
    Product Description

    NG-amino-L-Arginine inhibits nNOS, iNOS, and eNOS with Ki values of 0.3, 3, and 2.5 μM, respectively.1,2 Inhibition is mediated by covalent alteration of the heme prosthetic group leading to inactivation of the enzyme.1,2,3 NG-amino-L-Arginine can be used both in cell culture and in vivo.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wolff, D.J., and Lubeskie, A. Inactivation of nitric oxide synthase isoforms by diaminoguanidine and NG-amino-L-arginine. Arch. Biochem. Biophys. 325(2), 227-234 (1996).

    2. Vuletich, J.L., Lowe, E.R., Jianmongkol, S., et al. Alteration of the heme prosthetic group of neuronal nitric-oxide synthase during inactivation by NG-amino-L-arginine in vitro and in vivo. Mol. Pharmacol. 61(6), 110-118 (2002).

    3. Lee, A.J., Noon, K.R., Jianmongkol, S., et al. Metabolism of aminoguanidine, diaminoguanidine, and NG-amino-L-arginine by neuronal NO-synthase and covalent alteration of the heme prosthetic group. Chem. Res. Toxicol. 18(12), 1927-1933 (2005).

    4. Peng, H.M., Morishima, Y., Clapp, K.M., et al. Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination. Biochemistry 48, 8483-8490 (2009).

    5. Kellogg, D.L., Jr., Zhao, J.L., and Wu, Y. Endothelial nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo. Am. J. Physiol. Heart Circ. Physiol. 295, H123-H129 (2008).