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JWH 251

Item No. 10578

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2-methylphenyl)-1-(1-pentyl-1H-indol-3-yl)-ethanone
CAS Number
864445-39-6
Molecular Formula
C22H25NO
Formula Weight
319.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 2.5 mg/mlEthanol: 20 mg/ml
λmax
212, 246, 305 nm
SMILES
O=C(C1=CN(CCCCC)C2=C1C=CC=C2)CC3=C(C)C=CC=C3
InChi Code
InChI=1S/C22H25NO/c1-3-4-9-14-23-16-20(19-12-7-8-13-21(19)23)22(24)15-18-11-6-5-10-17(18)2/h5-8,10-13,16H,3-4,9,14-15H2,1-2H3
InChi Key
YBIPNGRKUAVSBG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $77

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    10 mg

    $145

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    25 mg

    $339

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    Cayman Chemical
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    Product Description

    JWH 251 is a cannabimimetic indole that shows a high affinity for the central cannabinoid (CB1) receptor with a Ki value of 29 nM and a comparatively modest affinity for the peripheral cannabinoid (CB2) receptor (Ki = 146 nM).1 JWH 251 stimulates GTPγS binding of CB1 and CB2 receptors with EC50 values of 29 and 8.3 nM, respectively.1 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huffman, J.W., Szklennik, P.V., Almond, A., et al. 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg. Med. Chem. Lett. 15(18), 4110-4113 (2005).

    Product Citations

    Ciolino, L.A. Quantitation of synthetic cannabinoids in plant materials using high performance liquid chromatography with UV detection (validated method). J. Forensic Sci. 60(5), 1171-1181 (2015).