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(−)-Neplanocin A

Item № 10584
CAS № 72877-50-0
Purity ≥98%
product image
                (CAS 72877-50-0)
     500 µg $221.00 0.00
     1 mg $420.00 0.00
     5 mg $1,728.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.


S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferase. (−)-Neplanocin A potently and irreversibly inactivates SAH hydrolase (Ki = 8.39 nM).1 It has antitumor activity against mouse leukemia L1210 cells and broad-spectrum antiviral activity.2,3,4,1 Neplanocin A is more potent against vesicular stomatitis than the reversible SAH hydrolase inhibitor 3-deazaneplanocin (ID50 = 0.07 and 0.3 μg/ml, respectively).3,5

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Technical Information
Formal Name
CAS Number
Molecular Formula
Formula Weight
A crystalline solid
262 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
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References & Product Citations
Product Description References

1. Borchardt, R.T., Keller, B.T., and Patel-Thombre, U. Neplanocin A. A potent inhibitor of S-adenosylhomocysteine hydrolase and of vaccinia virus multiplication in mouse L929 cells The Journal of Biological Chemisty 259(7), 4353-4358 (1984).

2. Yaginuma, S., Muto, N., Tsujino, M., et al. Studies on neplanocin A, new antitumor antibiotic. I. Producing organism, isolation and characterization Journal of Antibiotics 34(4), 359-366 (1981).

3. De Clercq, E. Antiviral and antimetabolic activities of neplanocins Antimicrobial Agents and Chemotherapy 28(1), 84-89 (1985).

4. Borcherding, D.R., Narayanan, S., Hasobe, M., et al. Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 11. Molecular dissections of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase Journal of Medicinal Chemistry 31, 1729-1738 (1988).

5. Tseng, C.K.H., Marquez, V.E., Fuller, R.W., et al. Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities Journal of Medicinal Chemistry 32, 1442-1446 (1989).

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