A Δ8-tetrahydrocannabinol analog
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KM 233

Item No. 10640

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6aR,7,10,10aR-tetrahydro-6,6,9-trimethyl-3-(1-methyl-1-phenylethyl)-6H-dibenzo[b,d]pyran-1-ol
CAS Number
628263-22-9
Molecular Formula
C25H30O2
Formula Weight
362.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 20 mg/mlEthanol: 3 mg/ml
SMILES
CC(C1=CC=CC=C1)(C)C2=CC(O)=C3C(OC(C)(C)[C@H]4[C@H]3CC(C)=CC4)=C2
InChi Code
InChI=1S/C25H30O2/c1-16-11-12-20-19(13-16)23-21(26)14-18(15-22(23)27-25(20,4)5)24(2,3)17-9-7-6-8-10-17/h6-11,14-15,19-20,26H,12-13H2,1-5H3/t19-,20-/m1/s1
InChi Key
GZYXCXRHVALIJD-WOJBJXKFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $76

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    5 mg

    $323

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    10 mg

    $608

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    25 mg

    $1,044

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    Cayman Chemical
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    Product Description

    KM 233 is a Δ8-tetrahydrocannabinol analog with a dimethyl substitution that exhibits high binding affinity for both the CB1 and CB2 receptors with 13-fold selectivity for the CB2 receptor (Kis = 12.3 and 0.91 nM, respectively).1 Demonstrating good lipophilicity and ability to penetrate the blood brain barrier, KM 233 inhibits human U87 glioma cell proliferation in vitro with an IC50 value of 1.4 μM and significantly reduces U87 glioma tumor size in vivo at a dose of 2 mg/kg in a SCID mouse xenograft side-pocket model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Krishnamurthy, M., Ferreira, A.M., and Moore, B.M., II Synthesis and testing of novel phenyl substituted side-chain analogues of classical cannabinoids. Bioorg. Med. Chem. Lett. 13(20), 3487-3490 (2003).

    2. Duntsch, C., Divi, M.K., Jones, T., et al. Safety and efficacy of a novel cannabinoid chemotherapeutic, KM-233, for the treatment of high-grade glioma. J. Neurooncol. 77(2), 143-152 (2006).