Hormone-Sensitive Lipase (human, recombinant)

Hormone-sensitive lipase (HSL) is a key enzyme regulating the mobilization of fatty acids from intracellular stores.¹ There are three different isoforms of the enzyme: HSL_adi, which is the predominant form found in adipocytes, HSL_tes expressed in testes, and HSL_b found in insulin secreting β-cells.² The three isoforms are distinguished by their molecular masses.² HSL catalyses the rate limiting step in the lipolysis of triacylglycerol, found in intracellular stores, to fatty acids.³ HSL also catalyzes the hydrolysis of mono- and diacylglycerides, as well as cholesterol esters.⁴

WARNING This product is not for human or veterinary use.

1. Holm, C., Belfrage, P., Osterlund, T., et al. Hormone-sensitive lipase: Structure, function, evolution and overproduction in insect cells using the baculovirus expression system. Protein Eng. 7(4), 537-541 (1994).

2. Krintel, C., Klint, C., Lindvall, H., et al. Quarternary structure and enzymological properties of the different hormone-sensitive lipase (HSL) isoforms. PLoS One 5(6), (2010).

3. Zimmermann, R., Lass, A., Haemmerle, G., et al. Fate of fat: The role of adipose triglyceride lipase in lipolysis. Biochim. Biophys. Acta 1791, 494-500 (2009).

4. Saltiel, A.R. Another hormone-sensitive triglyceride lipase in fat cells. Proc. Natl. Acad. Sci. USA 97(2), 535-537 (2000).