Selective antagonist of α3β4 nicotinic acetylcholine receptors
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Product Categories

Product Type

Small Molecule Modulators
Ion Channel Modulators

Research Area

SR 16584

Item No. 10683

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-dihydro-1-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-2H-indol-2-one
CAS Number
1150153-86-8
Molecular Formula
C17H22N2O
Formula Weight
270.4
Purity
≥95%
Formulation
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 0.3 mg/mlDMSO: 0.2 mg/mlEthanol: 0.5 mg/ml
λmax
205, 253 nm
SMILES
O=C(CC1=C2C=CC=C1)N2[C@@H]3C[C@H](N4C)CCC[C@H]4C3
InChi Code
InChI=1S/C17H22N2O/c1-18-13-6-4-7-14(18)11-15(10-13)19-16-8-3-2-5-12(16)9-17(19)20/h2-3,5,8,13-15H,4,6-7,9-11H2,1H3/t13-,14+,15-
InChi Key
GIDZCNCCCWFCIN-QDMKHBRRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $158

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    10 mg

    $215

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    Product Description

    Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels in the central and peripheral nervous system. SR 16584 is an antagonist of the α3β4 nAChR subtype (IC50 = 10.2 μM).1 It shows selective binding of the α3β4 subtype compared to the α4β2 and α7 subtypes (Ki values of 0.508, >100, and >100 μM, respectively), indicating that it should be a useful tool for receptor subtype studies.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zaveri, N., Jiang, F., Olsen, C., et al. Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. J. Med. Chem. 53(22), 8187-8191 (2010).