A natural agonist of PPARα
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9-oxo-10(E),12(E)-Octadecadienoic Acid

Item No. 10685

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-oxo-10E,12E-octadecadienoic acid
CAS Number
54232-58-5
Synonyms
  • 9-oxo ODA
Molecular Formula
C18H30O3
Formula Weight
294.4
Purity
≥90%
Formulation
A 5 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 16 mg/mlEthanol: 25 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
276 nm
SMILES
O=C(/C=C/C=C/CCCCC)CCCCCCCC(O)=O
InChi Code
InChI=1S/C18H30O3/c1-2-3-4-5-6-8-11-14-17(19)15-12-9-7-10-13-16-18(20)21/h6,8,11,14H,2-5,7,9-10,12-13,15-16H2,1H3,(H,20,21)/b8-6+,14-11+
InChi Key
LUZSWWYKKLTDHU-SIGMCMEVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $69

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    1 mg

    $127

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    5 mg

    $525

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    Product Description

    9-oxo-10(E),12(E)-Octadecadienoic acid (9-oxo ODA) is a natural agonist, abundant in tomatoes, that activates PPARα at 10-20 µM.1 It is produced from conjugated linoleic acid, which is also known to be a PPARα agonist.1,2 9-oxo ODA increases the expression of genes regulated by PPARα in primary mouse hepatocytes, altering lipid metabolism.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, Y.I., Hirai, S., Takahashi, H., et al. 9-oxo-10(E),12(E)-octadecadienoic acid derived from tomato is a potent PPAR α agonist to decrease triglyceride accumulation in mouse primary hepatocytes. Mol. Nutr. Food Res. 55(4), 585-593 (2010).

    2. Moya-Camarena, S.Y., Heuvel, J.P.V., Blanchard, S.G., et al. Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα. J. Lipid Res. 40(8), 1426-1433 (1999).