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Parent Compound(s)
10902JWH 20013171JWH 200 (exempt preparation)
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JWH 200 7-hydroxyindole metabolite

Item No. 10747

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(7-hydroxy-1-(2-morpholinoethyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone
Molecular Formula
C25H24N2O3
Formula Weight
400.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: 14 mg/mlDMF: 25 mg/mlDMF:PBS(pH 7.2)(1:6): 0.1 mg/mlDMSO: 20 mg/mlMethanol: 2 mg/ml
λmax
219, 353 nm
SMILES
O=C(C1=CN(CCN2CCOCC2)C3=C1C=CC(O)=C3)C4=CC=CC5=C4C=CC=C5
InChi Code
InChI=1S/C25H24N2O3/c28-23-10-4-8-20-22(17-27(24(20)23)12-11-26-13-15-30-16-14-26)25(29)21-9-3-6-18-5-1-2-7-19(18)21/h1-10,17,28H,11-16H2
InChi Key
CMMGHZRATLHDKO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    JWH 200 is an aminoalkylindole that acts as a cannabinoid (CB) receptor agonist, binding the CB1 receptor with high-affinity (IC50 = 7.8-42 nM).1,2 JWH 200 is one of several synthetic CBs which have been included in smoking mixtures.3 JWH 200 7-hydroxyindole metabolite is expected to be a urinary metabolite of JWH 200 based on the metabolism of the closely related JWH 015 and JWH 018.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eissenstat, M.A., Bell, M.R., D'Ambra, T.E., et al. Aminoalkylindoles: Structure-activity relationships of novel cannabinoid mimetics. J. Med. Chem. 38(16), 3094-3105 (1995).

    2. Huffman, J.W., Mabon, R., Wu, M.J., et al. 3-indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor. Bioorgan. Med. Chem. 11(4), 539-549 (2003).

    3. Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y. Survey of current trends in the abuse of psychotropic substances and plants in Japan. Leg. Med. (Tokyo) 13(3), 109-115 (2011).

    4. Zhang, Q., Ma, P., Cole, R.B., et al. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS. Anal. Bioanal. Chem. 386(5), 1345-1355 (2006).

    5. Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine. Forensic Sci. Int. 200(1-3), 141-147 (2010).