Pure human recombinant protein
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RIZ1 (human recombinant)

Item No. 10765

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • KMT8
  • PRDM2
  • PR Domain Zinc Finger Protein 2
  • Retinoblastoma Protein-interacting Zinc Finger Protein
Purity
≥85% estimated by SDS-PAGE
Source
recombinant N-terminal GST-tagged protein expressed in E. coli
Amino Acids
2-200 (C-terminal truncation)
MW
49.5 kDa
UniProt Accession №
Q13029
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    250 µg

    $395

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    Product Description

    Retinoblastoma protein-interacting zinc finger protein 1 (RIZ1), also known as PRDM2, is a SAM-dependent histone methyltransferase that specifically methylates histone H3 on lysine 9. RIZ1 contains 8 zinc-finger motifs and 1 PR domain.1,2 The RIZ gene encodes two different proteins, RIZ1 and RIZ2. RIZ1 is a tumor suppressor that can arrest the cell cycle and induce apoptosis. RIZ2 however, is a proto-oncoprotein lacking the N-terminal PR domain containing the methyltransferase activity.3 When RIZ1 is silenced or mutated, the reduced methyltransferase activity can lead to inheritable changes in chromatin methylation and gene expression patterns.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Buyse, I.M., Shao, G., and Huang, S. The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein. Proc. Natl. Acad. Sci. USA 92, 4467-4471 (1995).

    2. Xie, M., Shao, G., Buyse, I.M., et al. Transcriptional repression mediated by the PR domain zinc finger gene RIZ. The Journal of Biological Chemisty 272(42), 26360-26366 (1997).

    3. Liu, L., Shao, G., Steele-Perkins, G., et al. The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter. The Journal of Biological Chemisty 272(5), 2984-2991 (1997).

    4. Kim, K.C., Geng, L., and Huang, S. Inactivation of a histone methyltransferase by mutations in human cancers. Cancer Res. 63, 7619-7623 (2003).