Pure human recombinant enzyme
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UTX (human, recombinant)

Item No. 10774

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • KDM6A
  • Ubiquitously Transcribed Tetratricopeptide Repeat X
Purity
≥55% estimated by SDS-PAGE
Source
Recombinant N-terminal proprietary tagged protein expressed in E. coli
Amino Acids
930-1,410 (N-terminal truncation)
MW
70.5 kDa
Storage Buffer
50 mM Hepes, pH 7.4, containing 150 mM sodium chloride and 20% glycerol
UniProt Accession №
O15550
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    25 µg

    $423

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    Product Description

    Ubiquitously transcribed tetratricopeptide repeat X (UTX) gene codes for the widely-expressed UTX protein. The UTX gene is localized on the X chromosome and is a homolog of the ubiquitously transcribed mouse Y chromosome (UTY) gene. UTX gene expression has been shown to evade X-chromosome inactivation.1 The JmjC-containing UTX protein is a member of the hydroxylase family of enzymes, which are α-ketoglutarate-dependent Fe (II) oxygenases.2 UTX plays a crucial role in epigenetic regulation of gene expression by catalyzing the demethylation of tri-methylated lysine 27 on histone H3.3 UTX works in opposition to the polycomb repressive complex 2 (PRC2) group protein EZH2, playing a role in cancers with abberant H3K27 methylation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Greenfield, A., Carrel, L., Pennis, D., et al. The UTX gene escapes X inactivation in mice and humans. Hum. Mol. Genet. 7(4), 737-742 (1998).

    2. Hübner, M.R., and Spector, D.L. Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation. Cold Spring Harb. Symp. Quant. Biol. 75, 43-49 (2010).

    3. Agger, K., Cloos, P.A.C., Christensen, J., et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 449(7163), 731-734 (2011).