Potent agonist of muscarinic receptors
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Xanomeline (oxalate)

Item No. 10790

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl-pyridine, ethanedioate
CAS Number
141064-23-5
Synonyms
  • Lumeron
  • LY246708
  • Memcor
Molecular Formula
C14H23N3OS • C2H2O4
Formula Weight
371.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1.6 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/ml
λmax
223, 296 nm
SMILES
CCCCCCOC1=NSN=C1C2=CCCN(C)C2.OC(C(O)=O)=O
InChi Code
InChI=1S/C14H23N3OS.C2H2O4/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12;3-1(4)2(5)6/h8H,3-7,9-11H2,1-2H3;(H,3,4)(H,5,6)
InChi Key
ZJOUESNWCLASJP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $132

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    10 mg

    $176

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    Product Description

    Xanomeline (oxalate) is a potent agonist of muscarinic acetylcholine receptors (EC50 values are 0.3, 92.5, 5, 52, and 42 nM for M1, M2, M3, M4, and M5, respectively).1 It has antipsychotic-like activities in rats and Cebus monkeys.2,3 M1 selective agonists, like Xanomeline (oxalate), enhance memory function and has utility in treating Alzheimer’s Disease.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Heinrich, J.N., Butera, J.A., Carrick, T., et al. Pharmacological comparison of muscarinic ligands: Historical versus more recent muscarinic M1-preferring receptor agonists. Eur. J. Pharmacol. 605(1-3), 53-56 (2009).

    2. Stanhope, K.J., Mirza, N.R., Dickerdike, M.J., et al. The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat. J. Pharmacol. Exp. Ther. 299(2), 782-792.

    3. Andersen, M.B., Fink-Jensen, A., Peacock, L., et al. The muscarinic M1/M4 receptor agonist xanomeline exhibits antipsychotic-like activity in Cebus apella monkeys. Neuropsychopharmacology 28(6), 1168-1175 (2003).

    4. Messer, W.S., Jr. The utility of muscarinic agonists in the treatment of Alzheimer’s disease. J. Mol. Neurosci. 19(1-2), 187-193 (2002).