An inhibitor of tubulin polymerization and cancer cell growth
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Multidrug Resistance

CAY10647

Item No. 10791

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4-fluorophenyl)(2-(4-methoxyphenyl)-1H-imidazol-4-yl)methanone
CAS Number
1253697-49-2
Molecular Formula
C17H13FN2O2
Formula Weight
296.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 3 mg/ml
λmax
258, 325 nm
SMILES
COC1=CC=C(C2=NC(C(C3=CC=C(F)C=C3)=O)=CN2)C=C1
InChi Code
InChI=1S/C17H13FN2O2/c1-22-14-8-4-12(5-9-14)17-19-10-15(20-17)16(21)11-2-6-13(18)7-3-11/h2-10H,1H3,(H,19,20)
InChi Key
VKXVLHQVMBNLHX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $120

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    5 mg

    $530

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    10 mg

    $942

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    Cayman Chemical
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    Product Description

    CAY10647 is an aryl-benzoyl-imidazole which prevents proliferation of multidrug resistant cancer cells in vitro (IC50 = 28-63 nM) and inhibits melanoma xenograph tumor growth in vivo (10-30 mg/kg).1 This compound also binds to tubulin (Ki = 3.4 μM) and prevents tubulin polymerization.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, J., Wang, Z., Li, C.M., et al. Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents. J. Med. Chem. 53(20), 7414-7427 (2010).