A selective Δ6 desaturase inhibitor
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SC-26196

Item No. 10792

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α,α-diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
CAS Number
218136-59-5
Synonyms
  • α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
Molecular Formula
C27H29N5
Formula Weight
423.6
Purity
≥98%
Solubility(Learn about Variance in Solubility)
DMF: 12 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 5 mg/ml
λmax
303 nm
SMILES
N#CC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCN(/N=C/C4=CN=CC=C4)CC3
InChi Code
InChI=1S/C27H29N5/c28-23-27(25-10-3-1-4-11-25,26-12-5-2-6-13-26)14-8-16-31-17-19-32(20-18-31)30-22-24-9-7-15-29-21-24/h1-7,9-13,15,21-22H,8,14,16-20H2/b30-22+
InChi Key
QFYKXKMYVYOUNJ-JBASAIQMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

    $420

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    Product Description

    SC-26196 is an inhibitor of Δ6 desaturase (IC50 = 0.2 µM in a rat liver microsomal assay) that completely blocks the conversion of linoleic acid to arachidonic acid (AA).1 It is selective for Δ6 desaturase, as IC50 values for Δ5 and Δ9 desaturases exceed 200 µM and it has no effect on the conversion of dihomo-γ-linolenic acid to AA.1,2 SC-26196 is orally active in vivo, decreasing edema in the carrageenan paw edema model in mice.1 It also blocks aging-related increases in AA in myocardial cardiolipin in mice, attenuating contractile dysfunction without impacting mitochondrial oxidative stress.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Obukowicz, M.G., Welsch, D.J., Salsgiver, W.J., et al. Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J. Pharmacol. Exp. Ther. 287(1), 157-166 (1998).

    2. Harmon, S.D., Kaduce, T.L., Manuel, T.D., et al. Effect of the Δ6-desaturase inhibitor SC-26196 on PUFA metabolism in human cells. Lipids 38(4), 469-476 (2003).

    3. Mulligan, C.M., Le, C.H., deMooy, A.B., et al. Inhibition of Δ-6 desaturase reverses cardiolipin remodeling and prevents contractile dysfunction in the aged mouse heart without altering mitochondrial respiratory function. J. Gerontol. A Biol. Sci. Med. Sci. 69(7), 799-809 (2014).

    Product Citations

    Zhang, L.J., Salekeen, R., Soto-Palma, C., et al. Article polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells. Cell Press Blue 1(1), 100004 (2026).

    Laval, T., Pedró-Cos, L., Malaga, W., et al. De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis. eLife 10, e71946 (2021).