An inhibitor of RGS4
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CCG-50014

Item No. 10802

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione
CAS Number
883050-24-6
Molecular Formula
C16H13FN2O2S
Formula Weight
316.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
251 nm
SMILES
CC1=CC=C(N2SC(N(CC3=CC=C(F)C=C3)C2=O)=O)C=C1
InChi Code
InChI=1S/C16H13FN2O2S/c1-11-2-8-14(9-3-11)19-15(20)18(16(21)22-19)10-12-4-6-13(17)7-5-12/h2-9H,10H2,1H3
InChi Key
QUIIIYITNGOFEI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $30

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    CCG-50014 is an inhibitor of regulator of G protein signaling 4 (RGS4) (IC50 = 30 nM) and is > 20-fold selective for RGS4 over other RGS proteins.1 RGS proteins bind to the Gα subunits of activated heterotrimeric G proteins and accelerate the rate of GTP hydrolysis, acting as GTPase-activating proteins.1 CCG-50014 irreversibly binds and destabilizes RGS4 with no effect on Gα0, while blocking GTPase activity and Gα0-dependent translocation of RGS4 to the membrane.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Blazer, L.L., Zhang, H., Casey, E.M., et al. A nanomolar-potency small molecule inhibitor of regulator of G protein signaling (RGS) proteins. Biochemistry 50(15), 3181-3192 (2011).