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JWH 030

Item No. 10831

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-naphthalenyl(1-pentyl-1H-pyrrol-3-yl)-methanone
CAS Number
162934-73-8
Molecular Formula
C20H21NO
Formula Weight
291.4
Purity
≥98%
Formulation
A solution in methanol
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 20 mg/mlEthanol:PBS (pH 7.2) (1:1): InsoublePBS (pH 7.2): Insouble
λmax
217 nm
SMILES
O=C(C1=CN(CCCCC)C=C1)C2=C(C=CC=C3)C3=CC=C2
InChi Code
InChI=1S/C20H21NO/c1-2-3-6-13-21-14-12-17(15-21)20(22)19-11-7-9-16-8-4-5-10-18(16)19/h4-5,7-12,14-15H,2-3,6,13H2,1H3
InChi Key
VPBJQDBKZSHCPC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    JWH 030 (Item No. 10831) is a naphthoyl pyrrole cannabimimetic which activates the CB1 receptor (EC50 = 30.5 nM for rat, Ki = 87 nM for mouse) better than CB2 (EC50 = 552 nM for human CB2).1,2 JWH 030 is quite potent in vivo in the mouse spontaneous activity and tail flick (antinociception) assays (ED50 = 26.8 μM/kg).2 It also dose-dependently inhibits electrically-induced contractions of the mouse vas deferens (IC50 = 3.38 nM).3 This product is intended for forensic or research purposes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tarzia, G., Duranti, A., Tontini, A., et al. Synthesis and structure-activity relationships of a series of pyrrole cannabinoid receptor agonists. Bioorg. Med. Chem. 11(18), 3965-3973 (2003).

    2. Lainton, J.A.H., Huffman, J.W., Martin, B.R., et al. 1-Alkyl-3-(1-naphthoyl)pyrroles: A new class of cannabinoid. Tetrahedron Lett. 36(9), 1401-1404 (1995).

    3. Pertwee, R.G., Griffin, G., Lainton, J.A.H., et al. Pharmacological characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferens. Eur. J. Pharmacol. 284(3), 241-247 (1995).