SMAD3 Polyclonal Antibody

SMAD3, a member of the SMAD family of proteins, is involved in the TGF-β signaling cascade. A human homolog of Drosophila Mad protein, SMAD3 consists of an N-terminal DNA-binding MH1 domain, a linker region and a C-terminal MH2 domain. It is a receptor-regulated SMAD (R-SMAD) that functions downstream of TGF-β and activin receptors and mediates their signaling.^1,2 It is recruited by SARA (SMAD anchor for receptor activation) to the receptor kinase for phosphorylation. Upon phosphorylation, SMAD3 dissociates from SARA, forms a complex with SMAD4 and transmigrates into the nucleus where it complexes with other cofactors and acts as a transcription factor. It has an indispensable role in cell proliferation, differentiation, apoptosis and formation of ECM. Loss of SMAD3 results in childhood T cell leukemia.

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1. Shi, Y., and Massaro, A.F. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113, 685-700 (2003).

2. Qin, B.Y., Suvana, S.L., Correia, J.J., et al. Smad3 allostery links TGF-β receptor kinase activation to transcriptional control. Genes Dev. 16, 1950-1953 (2002).

Upadhyay, A.K., Chattopadhyay, P., Goyary, D., et al. Ixora Coccinea enhances cutaneous wound healing by upregulating the expression of collagen and basic fibroblast growth factor. ISRN Pharmacol. 2014, 751824 (2014).