A covalent inhibitor of PME-1
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ABL 127

Item No. 10833

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R)-3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine-1,2-dicarboxylic acid, 1,2-dimethyl ester
CAS Number
1073529-41-5
Molecular Formula
C17H20N2O5
Formula Weight
332.4
Purity
≥98%
Formulation (Request formulation change)
A 1 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMSO: ≥5mg mlEthanol: ≥1mg/ml
SMILES
COC(N(N(C(OC)=O)[C@@]1(C2=CC=CC=C2)C3CCCC3)C1=O)=O
InChi Code
InChI=1S/C17H20N2O5/c1-23-15(21)18-14(20)17(13-10-6-7-11-13,19(18)16(22)24-2)12-8-4-3-5-9-12/h3-5,8-9,13H,6-7,10-11H2,1-2H3/t17-/m0/s1
InChi Key
ZRHWCAFAIHTQKD-KRWDZBQOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $148

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    10 mg

    $274

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    Cayman Chemical
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    Product Description

    ABL 127 is a covalent aza-β-lactam inhibitor of protein phosphatase methylesterase-1 (PME-1; IC50 = 4.2 nM).1 It selectively inhibits PME-1 over 50 other serine hydrolases in MDA-MB-231 and HEK293T cell lysates at 10 μM. ABL 127 decreases proliferation of Ishikawa cells and migration of ECC-1 endometrial carcinoma cells when used at a concentration of 50 nM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bachovchin, D.A., Mohr, J.T., Speers, A.E., et al. Academic cross-fertilization by public screening yield a remarkable class of protein phosphatase methylesterase-1 inhibitors. Proc. Natl. Acad. Sci. USA 108(17), 6811-6816 (2011).

    2. Pusey, M., Bail, S., Xu, Y., et al. Inhibition of protein methylesterase 1 decreased cancerous phenotypes in endometrial adenocarcinoma cell lines and xenograft tumor models. Tumour Biol. 37(9), 11835-11842 (2016).