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Pyrovalerone (hydrochloride)

Item No. 10836

Restricted Product (Schedule V)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • Centroton
  • Thymergix
  • Valerophenone
Technical Information
Formal Name
1-(4-methylphenyl)-2-(1-pyrrolidinyl)-1-pentanone, monohydrochloride
CAS Number
1147-62-2
Molecular Formula
C16H23NO • HCl
Formula Weight
281.8
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.25 mg/mlDMSO: 0.1 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
255 nm
SMILES
CC1=CC=C(C(C(CCC)N2CCCC2)=O)C=C1
InChi Code
InChI=1S/C16H23NO/c1-3-6-15(17-11-4-5-12-17)16(18)14-9-7-13(2)8-10-14/h7-10,15H,3-6,11-12H2,1-2H3
InChi Key
SWUVZKWCOBGPTH-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
V
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Pyrovalerone (hydrochloride) is an inhibitor of the transporters for certain monoamine neurotransmitters, including dopamine and norepinephrine, preventing their uptake.1,2 It has been used clinically for the treatment of chronic fatigue, but is used infrequently due to problems with abuse and dependence. Pyrovalerone is a DEA Schedule V controlled substance. Pyrovalerone (hydrochloride) is for use in the forensic analysis of samples that may contain this compound. This product, the hydrochloride salt of pyrovalerone, has superior solubility in aqueous solvents, compared to the free base (Item No. 10817).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Heron, C., Costentin, J., and Bonnet, J.J. Evidence that pure uptake inhibitors including cocaine interact slowly with the dopamine neuronal carrier. Eur. J. Pharmacol. 264(3), 391-398 (1994).

    2. Meltzer, P.C., Butler, D., Deschamps, J.R., et al. 1-(4-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (pyrovalerone) analogs. A promising class of monoamine uptake inhibitors. J. Med. Chem. 49(4), 1420-1432 (2006).