An α2-adrenergic receptor agonist
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Guanabenz (hydrochloride)

Item No. 10851

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2,6-dichlorophenyl)methylene]-hydrazinecarboximidamide, monohydrochloride
CAS Number
23113-43-1
Synonyms
  • Wytensin
Molecular Formula
C8H8Cl2N4 • HCl
Formula Weight
267.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 5 mg/ml
λmax
222, 274 nm
SMILES
ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1.Cl
InChi Code
InChI=1S/C8H8Cl2N4.ClH/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;/h1-4H,(H4,11,12,14);1H/b13-4+;
InChi Key
UNWWUUPHJRAOMZ-GAYQJXMFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $50

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    50 mg

    $94

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    100 mg

    $176

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    Product Description

    Guanabenz is an α2-adrenergic receptor agonist (effective concentrations 10-100 nM) with hypotensive effects.1,2 It also competes for imidazoline I2-binding sites in brown adipose tissue (Ki = 97 nM).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sakakibara, Y., Muramatsu, I., Fujiwara, M., et al. Effects of guanabenz on the adrenergic mechanism in rabbit arterial strips. Jpn. J. Pharmacol. 31(6), 1029-1036 (1981).

    2. Sica, D.A. Centrally acting antihypertensive agents: An update. J. Clin. Hypertens. (Greenwich) 9(5), 399-405 (2007).

    3. Römer, L., Wurster, S., Savola, J.M., et al. Identification and characterization of the imidazoline I2b-binding sites in the hamster brown adipose tissue as a study model for imidazoline receptors. Arch. Physiol. Biochem. 111(2), 159-166 (2003).