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Histone H4 undergoes many modifications including acetylation, methylation, and phosphorylation that are important for regulation of gene transcription.1 Histone H4 peptide can be used as a target substrate for several of the histone modifying enzymes including lysine methyltransferases, arginine methyltransferases, acetyltransferases, and others.
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1. Covalent modifications of histones during development and disease pathogenesis. Nat. Struct. Mol. Biol. 14(11), 1008-1016 (2007).