A potent inhibitor of KIAA1363
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Product Type

Small Molecule Modulators
Small Molecule Inhibitors

Research Area

Cancer

JW 480

Item No. 10879

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-isopropylphenyl(2-(naphthalen-2-yl)ethyl)carbamate
CAS Number
1354359-53-7
Molecular Formula
C22H23NO2
Formula Weight
333.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:2): 0.3 mg/ml
λmax
225, 268 nm
SMILES
CC(C)C(C=CC=C1)=C1OC(NCCC2=CC3=CC=CC=C3C=C2)=O
InChi Code
InChI=1S/C22H23NO2/c1-16(2)20-9-5-6-10-21(20)25-22(24)23-14-13-17-11-12-18-7-3-4-8-19(18)15-17/h3-12,15-16H,13-14H2,1-2H3,(H,23,24)
InChi Key
PCNJGBMWAZRVEA-UHFFFAOYSA-N
License
Sold under license from The Scripps Research Institute.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    25 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    The transmembrane enzyme KIAA1363 (also known as AADACL1) controls the production of the monoalkylglycerol ether (MAGE) class of neutral ether lipids (NELs) in cancer cells.1 Hyperactivity of this 2-acetyl MAGE hydrolase is associated with tumor cell migration, invasion, survival, and growth.2 JW 480 acts as a potent, selective inhibitor of KIAA1361 (IC50s = 20 nM in mouse brain membrane proteomes and 6-12 nM in human PC3 prostate cancer cell proteomes), showing little cross reactivity with hormone-sensitive lipase, acetylcholinesterase, or other serine hydrolases.2 JW 480 is active in vivo, reducing PC3 tumor xenograft growth in immune-deficient SCID mice at an oral dose of 80 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chiang, K.P., Niessen, S., Saghatelian, A., et al. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chem. Biol. 13(10), 1041-1050 (2006).

    2. Chang, J.W., Nomura, D.K., and Cravatt, B.F. A potent a selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chem. Biol. 18(4), 476-484 (2011).