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(+)-CP 47,497

Item No. 10910

Restricted Product (Schedule I)
Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2[(1R,3S)-3-hydroxycyclohexyl]-5-(2-methyloctan-2-yl)phenol
CAS Number
134308-14-8
Molecular Formula
C21H34O2
Formula Weight
318.5
Purity
≥98%
Formulation
A crystalline solid
λmax
219, 276 nm
SMILES
O[C@@H]1C[C@H](C2=CC=C(C(C)(C)CCCCCC)C=C2O)CCC1
InChi Code
InChI=1S/C21H34O2/c1-4-5-6-7-13-21(2,3)17-11-12-19(20(23)15-17)16-9-8-10-18(22)14-16/h11-12,15-16,18,22-23H,4-10,13-14H2,1-3H3/t16-,18+/m1/s1
InChi Key
ZWWRREXSUJTKNN-AEFFLSMTSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $129

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    5 mg

    $511

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    Product Description

    CP 47,497 is a bicyclic CB analog with potent analgesic activity.1 It is comparable or more potent than Δ9-tetrahydrocannabinol in analgesic, motor depressant, anticonvulsant, and hypothermic effects in mice, rats, and dogs.2 The dextrorotatory enantiomer, (+)-CP 47,497 avidly binds the CB1 receptor (Ki = 4.15 nM).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Melvin, L.S., Johnson, M.R., Harbert, C.A., et al. A cannabinoid derived prototypical analgesic. J. Med. Chem. 27(1), 67-71 (1984).

    2. Weissman, A., Milne, G.M., and Melvin, L.S., Jr. Cannabimimetic activity from CP-47,497, a derivative of 3-phenylcyclohexanol. J. Pharmacol. Exp. Ther. 223(2), 516-523 (1982).

    3. Melvin, L.S., Milne, G.M., Johnson, M.R., et al. Structure-activity relationships defining the ACD-tricyclic cannabinoids: Cannabinoid receptor binding and analgesic activity. Drug Des. Discov. 13(2), 155-166 (1995).

    Product Citations

    Damodaran, S.E., and Madhan, S. Telavancin: A novel lipoglycopeptide antibiotic. J. Pharmacol. Pharmacother. 2(2), 135-137 (2011).