SUCNR1 Polyclonal Antibody

SUCNR1 is a 334 amino acid-containing membrane receptor, belonging to the G-protein coupled receptor 1 family, characterized by an extracellular N terminus, seven transmembrane regions, and an intracellular C terminus and playing a role in cell communication.^1,2 SUCNR1 is a receptor for the citric acid cycle intermediate succinate. It functions in establishing a neovascular network during development and in response to injury. SUCNR1, in response to increased succinate levels, regulates the production of numerous angiogenic factors, including VEGF, and also is involved in the modulation of platelet function. It is known to play an essential role in proliferative ischemic retinopathy and is an attractive target for treating diseases that stem from aberrant neovascularization in the mature retina such as diabetic retinopathy. Expression of SUCNR1 is common in kidney, liver, retina, platelets, and leukocytes.

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1. He, W., Miao, F.J., Lin, D.C., et al. Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors. Nature 429(6988), 188-193 (2004).

2. Wittenberger, T., Schaller, H.C., and Hellebrand, S. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. J. Mol. Biol. 307(3), 799-813 (2001).