An Analytical Reference Standard
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Parent Compound(s)
13636JWH 398 15686JWH 398 (exempt preparation)
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JWH 398 N-(4-hydroxypentyl) metabolite

Item No. 10943

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4-chloro-1-naphthalenyl)[1-(4-hydroxypentyl)-1H-indol-3-yl]-methanone
CAS Number
1537889-06-7
Molecular Formula
C24H22ClNO2
Formula Weight
391.9
Purity
≥98%
Formulation
A 10 mg/ml solution in methanol
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 25 mg/mlEthanol: 15 mg/ml
λmax
218, 317 nm
SMILES
CC(O)CCCN1C2=CC=CC=C2C(C(C3=CC=C(Cl)C4=C3C=CC=C4)=O)=C1
InChi Code
InChI=1S/C24H22ClNO2/c1-16(27)7-6-14-26-15-21(19-10-4-5-11-23(19)26)24(28)20-12-13-22(25)18-9-3-2-8-17(18)20/h2-5,8-13,15-16,27H,6-7,14H2,1H3
InChi Key
KDHNVFXZDOAZAI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    JWH 398 (Item No. 13636) is a synthetic cannabinoid (CB) that activates both central CB1 and peripheral CB2 receptors (Ki = 2.3 and 2.8 nM, respectively).1 It has been reported to be an adulterant of herbal products.2,3 JWH 398 N-(4-hydroxypentyl) metabolite is an expected phase I metabolite of JWH 398 (Item No. 13636), detectable in serum and urine. While similar hydroxylated phase I metabolites of synthetic CBs retain activity, the physiological properties of this compound have yet to be determined.4,5 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huffman, J.W. Cannabimimetic indoles, pyrroles, and indenes: Structure-activity relationships and receptor interactions. The cannabinoid receptors 49-95 (2009).

    2. Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y. Survey of current trends in the abuse of psychotropic substances and plants in Japan. Leg. Med. (Tokyo) 13(3), 109-115 (2011).

    3. Dresen, S., Ferreirós, N., Pütz, M., et al. Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds. J. Mass Spectrom. 45(10), 1186-1194 (2010).

    4. Brents, L.K., Reichard, E.E., Zimmerman, M., et al. Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity. PLoS One 6(7), e21917 (2011).

    5. Brents, L.K., Gallus-Zawala, A., Radominska-Pandya, A., et al. Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retainintermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutralantagonist to partial agonist activity. Biochem. Pharmacol. 83(7), 952-961 (2012).

    Product Citations

    Cho, B., Cho, H.S., Kim, J., et al. Simultaneous determination of synthetic cannabinoids and their metabolites in human hair using LC-MS/MS and application to human hair. Forensic Sci. Int. 306, 110058 (2020).