Sampling Tubes with PHMB

4-(hydroxymercuri)Benzoic Acid(PHMB) is used to inhibit cysteine-protease and acts as a reversible thiol-specific blocker. While blocking the acylated ghrelin degradation, it allows the AcetylCholine Esterase AChE™ used in SPI-Bio EIA kits to work normally, in contrast to serine-protease inhibitors. Neuropeptides and other short peptides are really sensitive to protease degradation. It is often necessary to add specific and potent inhibitors to avoid total loss of the biomarker. The PHMB containing tubes have been designed to accept 1 ml samples. The cryotubes are graduated, with a silicone washer seal and external threads. They can be stored at temperatures as low as -196°C but should be used only in the gas phase of liguid nitrogen. Thus, PHMB sampling tubes may be useful to measure any biomarker cleaved by cysteine-proteases.¹ [Bertin Catalog No. D31009]

WARNING This product is not for human or veterinary use.

1. Boyer, P.D. Spectrophotometric study of the reaction of protein sulfhydryl groups with organic mercurials. J. Am. Chem. Soc. 76(17), 4331-4337 (1954).