Natural curcuminoid with roles in cancer and inflammation
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Product Type

Biochemicals
Natural Products

Research Area

Cancer
Immunology & Inflammation

Demethoxycurcumin

Item No. 10961

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1E,6E-heptadiene-3,5-dione
CAS Number
22608-11-3
Synonyms
  • DMC
Molecular Formula
C20H18O5
Formula Weight
338.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 14 mg/mlDMSO: 10 mg/mlEthanol: 0.5 mg/ml
λmax
254, 421 nm
SMILES
OC1=CC=C(/C=C/C(CC(/C=C/C2=CC(OC)=C(O)C=C2)=O)=O)C=C1
InChi Code
InChI=1S/C20H18O5/c1-25-20-12-15(6-11-19(20)24)5-10-18(23)13-17(22)9-4-14-2-7-16(21)8-3-14/h2-12,21,24H,13H2,1H3/b9-4+,10-5+
InChi Key
HJTVQHVGMGKONQ-LUZURFALSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $110

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    10 mg

    $153

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    25 mg

    $369

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    Cayman Chemical
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    Product Description

    Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin. More stable than curcumin in physiological media, DMC suppresses proliferation in cancer cells at 50-100 μM.1 It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits lipopolysaccharide induction of iNOS.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sandur, S.K., Pandley, M.K., Ahn, K.S., et al. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis 28(8), 1765-1773 (2007).

    2. Ryu, M.J., Cho, M., Song, J.Y., et al. Natural derivatives of curcumin attenuate the Wnt/β-catenin pathway through down-regulation of the transcriptional coactivator p300. Biochem. Biophys. Res. Commun. 377(4), 1304-1308 (2008).