An unsaturated fatty acid found in royal jelly
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10-HDA

Item No. 10976

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10-hydroxy-2E-decenoic acid
CAS Number
14113-05-4
Synonyms
  • FA 10:1;O
Molecular Formula
C10H18O3
Formula Weight
186.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/ml
λmax
209 nm
SMILES
OCCCCCCC/C=C/C(O)=O
InChi Code
InChI=1S/C10H18O3/c11-9-7-5-3-1-2-4-6-8-10(12)13/h6,8,11H,1-5,7,9H2,(H,12,13)/b8-6+
InChi Key
QHBZHVUGQROELI-SOFGYWHQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $26

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    100 mg

    $73

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    500 mg

    $156

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    1 g

    $208

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    Product Description

    10-HDA is an unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees.1 10-HDA has longevity-promoting effects in C. elegans at a concentration of 25 μM.2 It down-regulates matrix metalloproteinases (MMPs) in rheumatoid arthritis synovial fibroblasts at a concentration of 1.25 nM and inhibits VEGF-induced angiogenesis in HUVECs at 500 μM.3,4 10-HDA also facilitates differentiation of neurons from neural stem/progenitor cells and promotes collagen production by skin fibroblasts at concentrations of 100 μM and 1.5 mM, respectively.5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kodai, T., Umebayashi, K., Nakatani, T., et al. Compositions of royal jelly II. Organic acid glycosides and sterols of the royal jelly of honeybees (Apis mellifera). Chem. Pharm. Bull. (Tokyo) 55(10), 1528-1531 (2007).

    2. Honda, Y., Fujita, Y., Maruyama, H., et al. Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans. PLoS One 6(8), 1-10 (2011).

    3. Wang, J.g., Ruan, J., Li, C.Y., et al. Connective tissue growth factor, a regulator related with 10-hydroxy-2-decenoic acid down-regulate MMPs in rheumatoid arthritis. Rheumatol. Int. 32(9), 2791-2799 (2011).

    4. Izuta, H., Chikaraishi, Y., Shimazawa, M., et al. 10-Hydroxy-2-decenoic acid, a major fatty acid from royal jelly, inhibits VEGF-induced angiogenesis in human umbilical vein endothelial cells. Evid. Based Complement. Alternat. Med. 6(4), 489-494 (2009).

    5. Hattori, N., Nomoto, H., Fukumitsu, H., et al. Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro. Biomed. Res. 28(5), 261-266 (2007).

    6. Koya-Miyata, S., Okamoto, I., Ushio, S., et al. Identification of a collagen production-promoting factor from an extract of royal jelly and its possible mechanism. Biosci. Biotechnol. Biochem. 68(4), 767-773 (2004).