A gastoprotective PGE2 analog
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Nocloprost

Item No. 10988

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9β-chloro-11α,15R-dihydroxy-16,16-dimethyl-prosta-5Z,13E-dien-1-oic acid
CAS Number
79360-43-3
Molecular Formula
C22H37ClO4
Formula Weight
401.0
Purity
≥98%
Formulation (Request formulation change)
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 11 mg/mlDMSO: 10 mg/mlEthanol: 16 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
SMILES
Cl[C@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)C(C)(C)CCCC)[C@H](O)C1
InChi Code
InChI=1S/C22H37ClO4/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-20,24-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6-,13-12+/t16-,17-,18-,19-,20-/m1/s1
InChi Key
AIOFTOLPMOTZKD-OPVFONCOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 µg

    $68

    Add

    500 µg

    $183

    Add

    1 mg

    $266

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Nocloprost is a stable prostaglandin E2 analog with gastroprotective and ulcer-healing properties. As a weak acid (pKa = 5), it accumulates in the gastric mucosa at low pH and can prevent the formation of gastric lesions in rats when administered intragastrically 30 minutes before 100% ethanol, acidified aspirin, acidified taurocholate, water immersion, or restraint stress (ID50s = 0.25, 0.58, 0.06 and 0.12 μg/kg, respectively).1 Additionally, nocloprost has been used to inhibit evoked acetylcholine release from isolated human bronchi (IC50 = 4 nM) to study factors that regulate human airway smooth muscle tone and secretion.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Konturek, S.J., Brzozowski, T., Drozdowicz, D., et al. Nocloprost, a unique prostaglandin E2 analog with local gastroprotective and ulcer-healing activity. Eur. J. Pharmacol. 195(3), 347-357 (1991).

    2. Reinheimer, T., Harnack, E., Racke, K., et al. Prostanoid receptors of the EP3 subtype mediate inhibition of evoked [3H]acetylcholine release from isolated human bronchi. Br. J. Pharmacol. 125(2), 271-276 (1998).