A calcium ionophore
Related Products
Alternative(s)
22030A23187 (calcium magnesium salt)
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

A23187

Item No. 11016

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl-4-benzoxazolecarboxylic acid
CAS Number
52665-69-7
Synonyms
  • Calcimycin
Molecular Formula
C29H37N3O6
Formula Weight
523.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 1 mg/ml
λmax
226, 279, 379 nm
SMILES
O=C([C@@H](C)[C@]1([H])[C@H](C)C[C@@H](C)[C@@]2(O[C@H](CC3=NC(C(C(O)=O)=C(NC)C=C4)=C4O3)[C@H](C)CC2)O1)C5=CC=CN5
InChi Code
InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1
InChi Key
HIYAVKIYRIFSCZ-CYEMHPAKSA-N
Origin
Bacterium/Streptomyces chartreusis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $43

    Add

    5 mg

    $86

    Add

    10 mg

    $151

    Add

    25 mg

    $269

    Add
    NET Formation Screening & Analysis Services
    Our experts are here to help.
    • Detection of NET formation ex vivo and screening for modulators using:
      • High-content imaging
      • Enzymatic detection
      • Citrullination/carbamylation detection
    • Experienced scientists skilled in neutrophil biology, isolation, and handling
    LEARN MORE
    Product Description

    A23187 is a calcium ionophore and a microbial metabolite that has been found in S. chartreusensis.1,2 It induces calcium overload and mitochondrial apoptosis in HEK293 cells when used at a concentration of 5 µM.1 A23187 (5 µM) induces the production of reactive oxygen species (ROS) and neutrophil extracellular trap (NET) formation in primary human neutrophils in a myeloperoxidase-, neutrophil elastase-, and citrullination-independent manner.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cho, S.-Y., Lee, J.-H., Bae, H.-D., et al. Transglutaminase 2 inhibits apoptosis induced by calcium-overload through down-regulation of Bax. Exp. Mol. Med. 42(9), 639-650 (2010).

    2. Kenny, E.F., Herzig, A., Krüger, R., et al. Diverse stimuli engage different neutrophil extracellular trap pathways. eLife 6, e24437 (2017).

    Product Citations

    Takahama, M., Wolfe, K.S., Richey, G., et al. Secreted phospholipase PLA2G5 acts as a hemolytic factor in sepsis. J. Clin. Invest. 136(9), e195001 (2026).