A selective inhibitor of PRMT4/CARM1
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PRMT4/CARM1 Inhibitor

Item No. 11033

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5-bis[(3-bromo-4-hydroxyphenyl)methylene]-1-(phenylmethyl)-4-piperidinone
CAS Number
1020399-49-8
Synonyms
  • Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1 Inhibitor
Molecular Formula
C26H21Br2NO3
Formula Weight
555.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:4): 0.2 mg/mLEthanol: 0.25 mg/mL
λmax
250, 367 nm
SMILES
BrC1=CC(/C=C2CN(CC3=CC=CC=C3)C/C(C\2=O)=C\C4=CC(Br)=C(O)C=C4)=CC=C1O
InChi Code
InChI=1S/C26H21Br2NO3/c27-22-12-18(6-8-24(22)30)10-20-15-29(14-17-4-2-1-3-5-17)16-21(26(20)32)11-19-7-9-25(31)23(28)13-19/h1-13,30-31H,14-16H2/b20-10+,21-11+
InChi Key
KNMFTTWVELIVCC-CLVAPQHMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $90

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    1 mg

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    5 mg

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    Cayman Chemical
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    Product Description

    PRMT4/CARM1 Inhibitor selectively blocks the activity of PRMT4/CARM1 with an IC50 value of 7.1 µM.1 It displays very low affinity towards PRMT1 and SET7 with IC50 values of 63 and 943 µM, respectively.1 In human prostate cancer LNCaP cells, this compound reduced the prostate-specific antigen promoter activity at 8-10 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheng, D., Valente, S., Castellano, S., et al. Novel 3,5-Bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: Enzyme selectivity and cellular activity. J. Med. Chem. 54(13), 4982-4932 (2011).