A selective autotaxin inhibitor
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Product Categories

Product Type

Small Molecule Modulators
Small Molecule Inhibitors
Phospholipases

Research Area

HA-155

Item No. 11034

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
B-[4-[[4-[[3-[(4-fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronic acid
CAS Number
1229652-22-5
Synonyms
  • Autotaxin Inhibitor IV
Molecular Formula
C24H19BFNO5S
Formula Weight
463.3
Purity
≥95% (mixture of isomers)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 30 mg/ml
λmax
224, 347 nm
SMILES
FC1=CC=C(CN2C(/C(SC2=O)=C/C3=CC=C(OCC4=CC=C(B(O)O)C=C4)C=C3)=O)C=C1
InChi Code
InChI=1S/C24H19BFNO5S/c26-20-9-3-17(4-10-20)14-27-23(28)22(33-24(27)29)13-16-5-11-21(12-6-16)32-15-18-1-7-19(8-2-18)25(30)31/h1-13,30-31H,14-15H2/b22-13-
InChi Key
BRWUZCBSWABPMR-XKZIYDEJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $117

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    10 mg

    $209

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    25 mg

    $436

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    Product Description

    HA-155 is a boronic acid-based compound that inhibits autotaxin (IC50 = 5.7 nM) by selectively binding to its catalytic threonine.1,2 It has been shown to dose-dependently block thrombin-induced LPA secretion in platelets.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hausmann, J., Kamtekar, S., Christodoulou, E., et al. Structural basis of substrate discrimination and integrin binding by autotaxin. Nat. Struct. Mol. Biol. 18(2), 198-204 (2011).

    2. Albers, H.M.H.G., Hendrickx, L.J.D., van Tol, R.J.P., et al. Structure-based design of novel boronic acid-based inhibitors of autotaxin. J. Med. Chem. 54(13), 4619-4626 (2011).

    3. Fulkerson, Z., Wu, T., Sunkara, M., et al. Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells. The Journal of Biological Chemisty 286(40), 34654-34663 (2011).