Pricing updated 2019-02-20. Prices are subject to change without notice.
17-AAG is an inhibitor of heat shock protein 90 (Hsp90) and a derivative of geldanamycin (Item No. 13355) that selectively inhibits BT474 tumor cell Hsp90 over fibroblast Hsp90 (IC50s = 5 and 943 nM, respectively).1 It inhibits the growth of prostate cancer cell lines (IC50s = 25-45 nM) and promotes the degradation of HER2 and induces growth arrest and apoptosis in breast cancer cells overexpressing HER2 (IC50s = 4-72 nM).2,3 In vivo, 17-AAG (25 mg/kg, i.p.) reduces tumor size in a G-415 gallbladder cancer mouse xenograft model.4
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Kamal, A., Thao, L., Sensintaffar, J., et al. A high-
Solit, D.B., Zheng, F.F., Drobnjak, M., et al. 17-
Münster, P.N., Marchion, D.C., Basso, A.D., et al. Degredation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3'-
Weber, H., Valbuena, J.R., Barbhuiya, M.A., et al. Small molecule inhibitor screening identifified HSP90 inhibitor 17-