A urea derivative of 17(18)-EpETE
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CAY10662

Item No. 11042

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
16-[[(ethylamino)carbonyl]amino]-11Z-hexadecenoic acid
CAS Number
1184844-74-3
Molecular Formula
C19H36N2O3
Formula Weight
340.5
Purity
≥98%
Formulation (Request formulation change)
A 100 µg/ml solution in methanol
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 3 mg/mlEthanol: 2 mg/ml
SMILES
CCNC(NCCCC/C=C\CCCCCCCCCC(O)=O)=O
InChi Code
InChI=1S/C19H36N2O3/c1-2-20-19(24)21-17-15-13-11-9-7-5-3-4-6-8-10-12-14-16-18(22)23/h7,9H,2-6,8,10-17H2,1H3,(H,22,23)(H2,20,21,24)/b9-7-
InChi Key
OUFBVXMGWWCVFO-CLFYSBASSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 µg

    $53

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    50 µg

    $98

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    100 µg

    $185

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    500 µg

    $813

    Add
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    Product Description

    17(R),18(S)-Epoxyeicosatetraenoic acid (17(R),18(S)-EpETE), a natural cytochrome P450 epoxygenase metabolite of eicosapentaenoic acid, is known to reduce the contraction rate of spontaneously beating heart cells and to protect neonatal rat cardiomyocytes against arrhythmias induced by β-adrenergic agonists (EC50 = ~ 1-2 nM).1 CAY10662 is a 1,3 disubstituted urea derivative of 17(R),18(S)-EpETE that is more metabolically robust and reduces the contractility of cardiomyocytes with improved potency (EC50 < 1 nM) over its parent compound.1 At concentrations 1,000-fold higher than required for the effect on cardiomyocytes, 1-5 μM CAY10662 exerts weak dose-dependent soluble epoxide hydrolase inhibition.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Falck, J.R., Wallukat, G., Puli, N., et al. 17(R),18(S)-Epoxyeicosatetraenoic acid, a potent eicosapentaenoic acid (EPA) derived regulator of cardiomyocyte contraction: Structure-activity relationships and stable analogues. J. Med. Chem. 54(12), 4109-4118 (2011).