A ceramidase inhibitor
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Ceranib-2

Item No. 11092

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone
CAS Number
1402830-75-4
Molecular Formula
C25H19NO3
Formula Weight
381.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:5): 0.15 mg/mlDMSO: 20 mg/ml
λmax
231, 338 nm
SMILES
O=C(N1)C(C(/C=C/C2=CC=C(OC)C=C2)=O)=C(C3=CC=CC=C3)C4=C1C=CC=C4
InChi Code
InChI=1S/C25H19NO3/c1-29-19-14-11-17(12-15-19)13-16-22(27)24-23(18-7-3-2-4-8-18)20-9-5-6-10-21(20)26-25(24)28/h2-16H,1H3,(H,26,28)/b16-13+
InChi Key
YIJGNIIQDRGGFT-DTQAZKPQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $69

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    10 mg

    $127

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    25 mg

    $297

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    50 mg

    $525

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    Cayman Chemical
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    Product Description

    Ceranib-2 is a ceramidase inhibitor that inhibits ceramidase activity (IC50 = 28 μM in SKOV3 cells).1 It also increases intracellular accumulation of various ceramides, including C14 ceramide (Item No. 22531), C24 ceramide (Item No. 62535), C26 ceramide, and C26:1 ceramide, and total ceramide levels and decreases levels of dihydrosphingosine, sphingosine, and sphingosine-1-phosphate (Item No. 22500) in SKOV3 cells. In vivo, ceranib-2 (20 and 50 mg/kg, i.p.) reduces tumor volume in a JC mammary adenocarcinoma mouse syngeneic tumor model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Draper, J.M., Xia, Z., Smith, R.A., et al. Discovery and evaluation of inhibitors of human ceramidase. Mol. Cancer Ther. 10(11), 2052-2061 (2011).

    Product Citations

    Ausman, J., Abbade, J., Ermini, L., et al. Ceramide-induced BOK promotes mitochondrial fission in preeclampsia. Cell death Dis. 9(3), 298 (2018).