A long-chain acylcarnitine with intracellular and extracellular roles
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Palmitoyl-DL-carnitine (chloride)

Item No. 11095

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-carboxy-N,N,N-trimethyl-2-[(1-oxohexadecyl)oxy]-1-propanaminium, monochloride
CAS Number
6865-14-1
Synonyms
  • C16:0 Carnitine
  • CAR 16:0
  • DL-Carnitine hexadecanoyl ester
  • DL-Carnitine palmitoyl ester
  • Hexadecanoyl-DL-carnitine
  • DL-Hexadecanoylcarnitine
  • NSC 628323
  • DL-Palmitoylcarnitine
Molecular Formula
C23H46NO4 • Cl
Formula Weight
436.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 14 mg/mlEthanol: 20 mg/ml
SMILES
CCCCCCCCCCCCCCCC(OC(C[N+](C)(C)C)CC(O)=O)=O.[Cl-]
InChi Code
InChI=1S/C23H45NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4;/h21H,5-20H2,1-4H3;1H
InChi Key
GAMKNLFIHBMGQT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

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    50 mg

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    500 mg

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    Product Description

    Palmitoyl-DL-carnitine is a long-chain acylcarnitine with both intracellular and extracellular roles. Within the cell, palmitoylcarnitine is transported into mitochondria to deliver palmitate for fatty acid oxidation and energy production.1 Exogenously added Palmitoyl-DL-carnitine alters calcium mobilization in many cell types.2,3,4 It also affects endothelial and epithelial tight junctions, reducing resistance and increasing permeability while decreasing cell viability.5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bezaire, V., Bruce, C.R., Heigenhauser, G.J.F., et al. Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: Essential role in fatty acid oxidation. Am. J. Physiol. Endocrinol. Metab. 290(3), E509-E515 (2006).

    2. El-Hayek, R., Valdivia, C., Valdivia, H.H., et al. Activation of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum by palmitoyl carnitine. Biophys. J. 65(2), 779-789 (1993).

    3. Stapleton, S.R., Currie, K.P.M., Scott, R.H., et al. Palmitoyl-DL-carnitine has calcium-dependent effects on cultured neurones from rat dorsal root ganglia. Br. J. Pharmacol. 107, 1192-1197 (1992).

    4. Muraki, K., and Imaizumi, Y. A novel action of palmitoyl-L-carnitine in human vascular endothelial cells. J. Pharmacol. Sci. 92, 252-258 (2003).

    5. Duizer, E., van der Wulp, C., Versantvoort, C.H.M., et al. Absorption enhancement, structural changes in tight junctions and cytotoxicity caused by palmitoyl carnitine in Caco-2 and IEC-18 cells. J. Pharmacol. Exp. Ther. 287(1), 395-402 (1998).

    6. Ma, L., Kuang, K., Smith, R.W., et al. Modulation of tight junction properties relevant to fluid transport across rabbit corneal endothelium. Exp. Eye Res. 84(4), 790-798 (2007).