A polysulfonated naphthylurea with antiviral, antiparasitic, and anticancer activities
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Suramin (sodium salt)

Item No. 11126

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid, hexasodium salt
CAS Number
129-46-4
Synonyms
  • BAY 205
  • Germanin
  • NF 060
Molecular Formula
C51H34N6O23S6 • 6Na
Formula Weight
1429.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: >10 mg/ml
SMILES
O=C(C1=CC=C(C)C(NC(C2=CC(NC(NC3=CC(C(NC4=C(C)C=CC(C(NC5=C(C(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C6)C6=C(S(=O)([O-])=O)C=C5)=O)=C4)=O)=CC=C3)=O)=CC=C2)=O)=C1)NC7=CC=C(S(=O)([O-])=O)C8=C7C(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C8.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)
InChi Key
VAPNKLKDKUDFHK-UHFFFAOYSA-H
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $129

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    250 mg

    $306

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    Product Description

    Suramin is a polysulfonated naphthylurea with antiviral, antiparasitic, and anticancer activities.1 It is negatively charged at physiological pH and, therefore, binds to various intracellular targets including, but not limited to, ryanodine receptor 1 (IC50 = 4.9 µM), G protein-coupled receptors, purinergic P2 receptors, PDGF, PKC, transferrin, DNA and RNA polymerases, sirtuins, and various cytokines.1,2,3 It reduces Zika virus infectivity in Vero cells (IC50 = ~2.5-5 µg/ml).4 Suramin reduces the proliferation of bloodstream forms of T. brucei (MIC = 0.1 µM).5 It also neutralizes the myotoxic effect of the basic phospholipase A2 (PLA2) homolog MjTX-I, a Lys49-PLA2 protein from snake venom, in mouse phrenic-diaphragm preparations.6 Suramin (60 mg/kg) reduces tumor volume in patient-derived xenograft (PDX) mouse models of malignant mesothelioma.7 Formulations containing suramin have been used in the treatment of African sleeping sickness.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wiedemar, N., Hauser, D.A., and Mäser, P. 100 years of suramin. Antimicrob. Agents Chemother. 64(3), e01168-01119 (2020).

    2. Klinger, M., Bofill-Cardona, E., Mayer, B., et al. Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites. Biochem. J. 355(3), 827-833 (2001).

    3. Charlton, S.J., Brown, C.A., Weisman, G.A., et al. PPADS and suramin as antagonists at cloned P2Y- and P2U- purinoceptors. Br. J. Pharmacol. 118(3), 704-710 (1996).

    4. Tan, C.W., Sam, I.-C., Chong, W.L., et al. Polysulfonate suramin inhibits Zika virus infection. Antiviral Res. 143, 186-194 (2017).

    5. Steverding, D., Tinson, R.A.J., Piras, M., et al. Suramin: Effectiveness of analogues reveals structural features that are important for the potent trypanocidal activity of the drug. Exp. Parasitol. 260, 108744 (2024).

    6. Salvador, G.H.M., Dreyer, T.R., Gomes, A.A.S., et al. Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanism. Sci. Rep. 8(1), 10317 (2018).

    7. Chahinian, A.P., Mandeli, J.P., Gluck, H., et al. Effectiveness of cisplatin, paclitaxel, and suramin against human malignant mesothelioma xenografts in athymic nude mice. J. Surg. Oncol. 67(2), 104-111 (1998).