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Formation of cis monoenoic acids from unsaturated fatty acids, such as palmitoleic acid (9-cis-hexadecenoic acid) from palmitic acid occurs readily in animal tissues.1 Δ2-trans-Hexadecenoic acid is an intermediate formed in the β-oxidation of palmitic acid.2 In a model meant to simulate gastric ulceration, Δ2-trans-hexadecenoic acid at 10 mg/kg significantly inhibits gastric juice secretion in pylorus-ligated rats.3
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1. Enzymatic formation of hexadecenoic acid from palmitic acid. Agr. Biol. Chem. 39(3), 707-710 (1975).
2. Synthesis and characterization of 3-
3. Inhibitory effects of unsaturated fatty acids of trans-