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Dimethocaine (hydrochloride)

Item No. 11159

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(diethylamino)-2,2-dimethyl-1-(4-aminobenzoate)-1-propanol, monohydrochloride
CAS Number
553-63-9
Molecular Formula
C16H26N2O2 • HCl
Formula Weight
314.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 14 mg/mlEthanol: 16 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
222, 297 nm
SMILES
NC1=CC=C(C(OCC(C)(C)CN(CC)CC)=O)C=C1.Cl
InChi Code
InChI=1S/C16H26N2O2.ClH/c1-5-18(6-2)11-16(3,4)12-20-15(19)13-7-9-14(17)10-8-13;/h7-10H,5-6,11-12,17H2,1-4H3;1H
InChi Key
WWTWKTDXBNHESE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Dimethocaine is a local anesthetic that, because of its similarity in action to cocaine, has potential for abuse. This compound completely inhibits dopamine uptake in rat striatal synaptosomes with an IC50 value of 1.2 µM comparable to that of cocaine (IC50 = 0.7 µM).1 As a result, dimethocaine dose-dependently substitutes for cocaine in drug discrimination tests in rats and rhesus monkeys.2,3 This product is intended for forensic and research purposes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Woodward, J.J., Compton, D.M., Balster, R.L., et al. In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter. Eur. J. Pharmacol. 277(1), 7-13 (1995).

    2. Graham, J.H., and Balster, R.L. Cocaine-like discriminative stimulus effects of procaine, dimethocaine and lidocaine in rats. Psychopharmacology (Berl) 110(3), 287-294 (1993).

    3. Wilcox, K.M., Kimmel, H.L., Lindsey, K.P., et al. In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys. Synapse 58(4), 220-228 (2005).