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A-834735

Item No. 11163

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)-methanone
CAS Number
895155-57-4
Molecular Formula
C22H29NO2
Formula Weight
339.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 3 mg/mlEthanol: 5 mg/mlEthanol:PBS(pH 7.2) (1:5): 0.16 mg/mlMethanol: 1 mg/ml
λmax
217, 246, 304 nm
SMILES
O=C(C1C(C)(C)C1(C)C)C2=CN(CC3CCOCC3)C4=CC=CC=C42
InChi Code
InChI=1S/C22H29NO2/c1-21(2)20(22(21,3)4)19(24)17-14-23(13-15-9-11-25-12-10-15)18-8-6-5-7-16(17)18/h5-8,14-15,20H,9-13H2,1-4H3
InChi Key
NQTMRZNYLIGQCF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    A-834735 is an indole-derived cannabinoid (CB) with a 3-tetramethylcyclopropylmethanone substituent. It acts as a full agonist at both the central CB1 and peripheral CB2 receptors in rat with Ki values of 4.6 and 0.31 nM, respectively. and EC50 values of 12 and 0.21 nM, respectively.1 A-834735 readily crosses the blood-brain barrier, dose-dependently reversing thermal hyperalgesia without adverse side effects in a rat neuropathic pain model.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chin, C.L., Tovcimak, A.E., Hradil, V.P., et al. Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI. Br. J. Pharmacol. 153(2), 367-379 (2008).

    Product Citations

    Fréreux, C., Karam, J.A.Q., Howley, B.V., et al. PCBP1 binding to single-stranded poly-cytosine motifs enhances cGAS sensing and impairs breast cancer development. Commun. Biol. 9(1), 179 (2026).