A Glut1 inhibitor
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STF-31

Item No. 11173

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinyl-benzamide
CAS Number
724741-75-7
Molecular Formula
C23H25N3O3S
Formula Weight
423.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:5): 0.2 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/ml
λmax
231, 264 nm
SMILES
O=C(C1=CC=C(CNS(=O)(C2=CC=C(C(C)(C)C)C=C2)=O)C=C1)NC3=CN=CC=C3
InChi Code
InChI=1S/C23H25N3O3S/c1-23(2,3)19-10-12-21(13-11-19)30(28,29)25-15-17-6-8-18(9-7-17)22(27)26-20-5-4-14-24-16-20/h4-14,16,25H,15H2,1-3H3,(H,26,27)
InChi Key
NGQPRVWTFNBUHA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    STF-31 is an inhibitor of Glut1 (IC50 = ~1 µM) that blocks glucose uptake.1 It induces necrosis in cancer cells that lack the von Hippel-Lindau tumor suppressor gene, which overexpress Glut1.1 Although STF-31 binds Glut1, suggesting a direct effect, STF-31 also inhibits nicotinamide phosphoribosyltransferase, an enzyme that induces Glut1 expression.1,2,3 STF-31 is also toxic to human pluripotent stem cells (hPSCs) and can be used to selectively eliminate hPSCs from mixed cultures.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chan, D.A., Sutphin, P.D., Nguyen, P., et al. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci. Transl. Med. 3(94), 1-9 (2011).

    2. Adams, D.J., Ito, D., Rees, M.G., et al. NAMPT is the cellular target of STF-31-like small-molecule probes. ACS Chem. Biol. 9(10), 2247-2254 (2014).

    3. Garten, A., Petzold, S., Körner, A., et al. Nampt: Linking NAD biology, metabolism, and cancer. Trends Endocrinol. Metab. 20(3), 130-138 (2009).

    4. Boheler, K.R., Bhattacharya, S., Kropp, E.M., et al. A human pluripotent stem cell surface N-glycoproteome resource reveals markers, extracellular epitopes, and drug targets. Stem Cell Reports 3, 185-203 (2014).