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1-(3-Trifluoromethylphenyl)piperazine (hydrochloride)

Item No. 11205

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • TFMPP
  • 1-(m-Trifluoromethylphenyl)piperazine
  • 1-(meta-Trifluoromethylphenyl)piperazine
Technical Information
Formal Name
1-[3-(trifluoromethyl)phenyl]-piperazine, dihydrochloride
CAS Number
76835-14-8
Molecular Formula
C11H13F3N2 • 2HCl
Formula Weight
303.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
249, 293 nm
SMILES
FC(C1=CC=CC(N2CCNCC2)=C1)(F)F.Cl.Cl
InChi Code
InChI=1S/C11H13F3N2.2ClH/c12-11(13,14)9-2-1-3-10(8-9)16-6-4-15-5-7-16;;/h1-3,8,15H,4-7H2;2*1H
InChi Key
JCUKFOWDFVZILY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    1-(3-Trifluoromethylphenyl)piperazine (TFMPP) is an entactogenic drug which selectively promotes the release of serotonin.1 When used in combination with 1-benzylpiperazine, TFMPP increases both serotonin and dopamine, mirroring the effects of 3,4-methylenedioxymethamphetamine.1 Drug-drug synergism may induce seizures.1 TFMPP has been identified in party pills and powders.2,3 Its metabolism in rats has been described.4 This product is intended for forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baumann, M.H., Clark, R.D., Budzynski, A.G., et al. N-substituted piperazines abused by humans mimic the molecular mechanism of 3,4-methylenedioxymethamphetamine (MDMA, or “Ecstasy”). Neuropsychopharmacology 30(3), 550-560 (2005).

    2. Hill, S.L., and Thomas, S.H. Clinical toxicology of newer recreational drugs. Clin. Toxicol. (Phila) 49(8), 705-719 (2011).

    3. Arbo, M.D., Bastos, M.L., and Carmo, H.F. Piperazine compounds as drugs of abuse. Drug Alcohol Depend. 122(3), 174-185 (2012).

    4. Staack, R.F., and Maurer, H.H. Metabolism of designer drugs of abuse. Curr. Drug Metab. 6(3), 259-274 (2005).