An internal standard for the quantification of tetranor-PGDM lactone
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Unlabeled Version(s)
13564tetranor-PGDM lactone
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tetranor-PGDM lactone-d6

Item No. 11213

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5α-hydroxy-7,11-dioxo-2,3,4,5-tetranor-prostan-1,14-dioic acid-16,16,17,17,18,18-d6
Synonyms
  • tetranor-Prostaglandin D Metabolite lactone-d6
Molecular Formula
C16H16D6O6
Formula Weight
316.4
Purity
≥99% deuterated forms (d1-d6)
Formulation
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O=C(C([2H])([2H])C([2H])([2H])C([2H])([2H])CC(O)=O)CC[C@H]1C(C[C@H]2[C@@H]1CCC(O2)=O)=O
InChi Code
InChI=1S/C16H22O6/c17-10(3-1-2-4-15(19)20)5-6-11-12-7-8-16(21)22-14(12)9-13(11)18/h11-12,14H,1-9H2,(H,19,20)/t11-,12-,14+/m1/s1/i1D2,2D2,3D2
InChi Key
KRZCZJUXOKTLEH-OHTFLIHSSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    25 µg

    $267

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    100 µg

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    Product Description

    tetranor-PGDM lactone-d6 contains six deuterium atoms at the 16, 16', 17, 17', 18 and 18' positions. It is intended for use as an internal standard for the quantification of tetranor-PGDM lactone by GC- or LC-mass spectrometry. PGD2 plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle.1 tetranor-PGDM is an abundant urinary metabolite of PGD2 that is detectable both in human and mouse and, as such, is used as a biomarker of PGD2 biosynthesis.2 tetranor-PGDM lactone is a closed form of tetranor-PGDM. The formation of tetranor-PGDM lactone in biological samples has not been evaluated.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Giles, H., and Leff, P. The biology and pharmacology of PGD2. Prostaglandins 35(2), 277-300 (1988).

    2. Song, W.L., Wang, M., Ricciotti, E., et al. Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans. The Journal of Biological Chemisty 283(2), 1179-1188 (2008).