Water-soluble analog of forskolin
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NKH477 (hydrochloride)

Item No. 11214

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-β-alanine, N,N-dimethyl-oxo-1H-naphtho[2,1-b]pyran-6-yl ester, monohydrochloride
CAS Number
138605-00-2
Synonyms
  • Adehl
  • Colforsin Dapropate
  • Colforsin Daropate
Molecular Formula
C27H43NO8 • HCl
Formula Weight
546.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 2.5 mg/ml
SMILES
O=C1C[C@@](C=C)(C)O[C@]2(C)[C@@H](OC(C)=O)[C@@H](OC(CCN(C)C)=O)[C@@]3([H])C(C)(C)CC[C@H](O)[C@]3(C)[C@]21O.Cl
InChi Code
InChI=1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1
InChi Key
VIRRLEDAYYYTOD-YHEOSNBFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $109

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    10 mg

    $198

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    Product Description

    Forskolin (Item No. 11018) is a potent activator of adenylyl cyclase, but it is sparingly soluble in aqueous solutions. NKH477 is a water-soluble analog of forskolin which has both inotropic and vasodilator effects when administered intravenously.1,2,3 Like forskolin, NKH477 activates adenylyl cyclases without altering the activity of phosphodiesterases or sodium/potassium ATPases.1 This compound stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms.4 NKH477 relaxes guinea pig tracheal smooth muscle precontracted with histamine with an EC50 value of 32.6 nM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hosono, M., Takahira, T., Fujita, A., et al. Cardiovascular and adenylate cyclase stimulant properties of NKH477, a novel water-soluble forskolin derivative. J. Biomed. Sci. 19(4), 625-634 (1992).

    2. Sanbe, A., and Takeo, S. Effects of NKH477, a water-soluble forskolin derivative, on cardiac function in rats with chronic heart failure after myocardial infarction. J. Pharmacol. Exp. Ther. 274(1), 120-126 (1995).

    3. Satake, K., Takagi, K., Kodama, I., et al. Relaxant effects of NKH477, a new water-soluble forskolin derivative, on guinea-pig tracheal smooth muscle: The role of Ca2+-activated K+ channels. Br. J. Pharmacol. 123(4), 753-761 (1998).

    4. Toya, Y., Schwencke, C., and Ishikawa, Y. Forskolin derivatives with increased selectivity for cardiac adenylyl cyclase. J. Mol. Cell. Cardiol. 30(1), 97-108 (1998).