A marker for the detection of PE lipids by mass spectrometry
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Product Categories

Product Type

Biochemicals

Research Area

Lipid Biochemistry
Glycerophospholipids

Application

Mass Spectrometry

DMABA NHS ester

Item No. 11216

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(dimethylamino)-benzoic acid, 2,5-dioxo-1-pyrrolidinyl ester
CAS Number
58068-85-2
Synonyms
  • 4-(dimethylamino) Benzoic Acid
  • DMABA N-hydroxysuccinimide ester
  • N-Succinimidyl 4-(dimethylamino)benzoate
Molecular Formula
C13H14N2O4
Formula Weight
262.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:30): 0.03 mg/mlEthanol: InsoluablePBS (pH 7.2): Insoluable
λmax
235,323 nm
SMILES
O=C(CC1)N(OC(C2=CC=C(N(C)C)C=C2)=O)C1=O
InChi Code
InChI=1S/C13H14N2O4/c1-14(2)10-5-3-9(4-6-10)13(18)19-15-11(16)7-8-12(15)17/h3-6H,7-8H2,1-2H3
InChi Key
FNGFZOAQGYOQTG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    Product Description

    Phosphatidylethanolamine (PE) lipids are important components of cell membranes and biochemical pathways of fatty acid synthesis that contain abundant polyunsaturated fatty acyl (PUFA) groups. Oxidation of these phospholipids may be linked to various human diseases. DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids.1,2 This facilitates the use of electrospray tandem mass spectrometry for the detection of diacyl, ether, and plasmalogen PE lipids that cannot be readily observed otherwise.1,2 DMABA NHS ester has been used in combination with DMABA NHS ester-d4, -d6, and -d10 (Item Nos. 11217, 11218, and 11219) to study relative changes in PE lipid abundance before and after radical oxidation.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zemski Berry, K.A., Turner, W.W., VanNieuwenhze, M.S., et al. Stable isotope labeled 4-(dimethylamino)benzoic acid derivatives of glycerophosphoethanolamine lipids. Anal. Chem. 81(16), 6633-6640 (2009).

    2. Zemski Berry, K.A., Turner, W.W., VanNieuwenhze, M.S., et al. Characterization of oxidized phosphatidylethanolamine derived from RAW 264.7 cells using 4-(dimethylamino)benzoic acid derivatives. Eur. J. Mass Spectrom. (Chichester) 16(3), 463-470 (2010).